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Biomarkers

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Biomarkers

New Biomarkers of ALS

  • MUNIX
  • Neurofilament
  • Tau protein
  • Blood biomarkers

Motor Unit Number Index (MUNIX) :

  • Determines number of lower motor neurons supplying a muscle (i.e. motor unit)
  • Can be done before clinical weakness becomes apparent by manual muscle testing
  • MUNIX is more sensitive to change compared to CMAP and ALSFRS-R
  • This makes MUNIX a biomarker candidate for disease progression

Motor Unit Number Index (MUNIX) :

Neurofilament:

  • Among the altered biomarkers, CSF Nf-L level remains the best marker of ALS severity, while serum levels correlate strongly with disease progression. The combination of Nf-L and ICAM-1 concentrations in the CSF and IFN-γ concentration in the serum differentiate ALS patients.

Neurofilament:

Tau Protein:

  • Tau is a protein that stabilizes the cells’ skeleton via an intermediate phosphorylated Tau (pTau) form
  • ALS patients have significantly greater levels of total tau than controls
  • Ratio between pTau and total tau is significantly lower in ALS patients, indicating hyperphosphorylation- causes protien clumping

Tau Protein:

Blood biomarkers:

Conclusions
This study suggests that
  • Serum Creatinine
  • Albumin
  • CRP, and
  • Glucose
Measured at the time of ALS diagnosis as well as their changes after ALS diagnosis could serve as additional prognostic biomarkers for ALS.

Blood biomarkers:

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We are a dedicated group towards well being of people with MND and their families. We understand the difficult problems they have to face due to the disease. We are well aware of their special needs and challenges to be met. We support them in all possible ways.

Facebook X-twitter Instagram Youtube

Get in Touch

Donate Now

+91-9819741333

+91-8104546479

ashaekhope@gmail.com

Supported by :

Quick Links

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MND Clinic

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Addresses

Clinic Address :

Plot No: 19, Sector 40, Near Seawoods Grand Central Railway Station, Off, Palm Beach Rd, Seawoods, Navi Mumbai, Maharashtra 400706

Registered Address :
402, Guruprabha Apartment, S. B. Road, Dadar West, Mumbai – 400028, Maharashtra, India
Facebook X-twitter Youtube

We are a dedicated group towards well being of people with MND and their families. We understand the difficult problems they have to face due to the disease. We are well aware of their special needs and challenges to be met. We support them in all possible ways.

Facebook X-twitter Instagram Youtube

Get in Touch

Donate Now

+91-9819741333

+91-8104546479

ashaekhope@gmail.com

Supported by :

Quick Links

Home

About Us

MND Clinic

Donate Now

Terms & Conditions

Privacy Policy

Facebook X-twitter Youtube

Addresses

Clinic Address :

Plot No: 19, Sector 40, Near Seawoods Grand Central Railway Station, Off, Palm Beach Rd, Seawoods, Navi Mumbai, Maharashtra 400706

Registered Address :
402, Guruprabha Apartment, S. B. Road, Dadar West, Mumbai – 400028, Maharashtra, India
Copyright ©2025 All rights reserved by Asha Ek Hope Foundation.
Designed, Maintained & SEO by